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The present study confirmed that the WT1 gene was alternatively spliced at Ex4a to produce isoforms with opposing roles in apoptosis, anti-apoptotic isoforms (main WT1 isoforms) and pro-apoptotic isoform (truncated Ex4a(+)WT1 isoform). Many other genes concerned in apoptosis, this kind of as p53 [39], Survivin [40], Fas [41], and caspase-9 [42] are known to make isoforms with opposing roles in adv

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